Bookmakers will no longer be able to open near schools, hospitals or places where gamblers anonymous meetings take place in Tower Hamlets.
The council has revised its gambling policy to "protect children and vulnerable adults", a spokesman said.
The borough already enforces some of the strictest gambling rules in the country. The last new betting shop to be approved by the council was a Paddy Power in Roman Road, which opened five years ago.
But the new policy means the local authority can restrict the opening of gambling venues near playgrounds, old people's homes as well as hospitals or near where gamblers anonymous meetings might be held.
Ann Sutcliffe, corporate director, said: "We know that gambling can take people down a difficult path and that the young, the vulnerable and those experiencing financial hardship are at particular risk of being lured in.
"Having a strong gambling policy provides us with the powers to stem the proliferation of new premises, to stop gambling and debt becoming a trigger for crime and disorder, while also preventing the targeting of children and vulnerable people."
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here